COMBO-4-STROKE, new project funded by FIPSE

 

FIPSE (Fundación para la Innovación y la Prespectiva en Salud en España) has recently funded our project entitled: COMBO-4-Stroke.

The aim of these grants is financing feasibility studies that make it possible to put new healthcare technologies, based technically and financially viable, at the disposal of health services, and make it possible for them to be incorporated in the Spanish healthcare system.

In this project we want to keep on working with two promising treatments, based on
the synergic effects of two-by-two combinations of drugs previously approved by the FDA for other medical indications. We have found promising neuroprotective effects in pre-clinical experimentation: both drug combinations – but not individual drugs – are highly effective in reducing the brain ischemic lesion in animals following ischemic stroke. Our multidisciplinary team of clinicians and biologists strongly believes that the use of these combinations of drugs (COMBO-4-STROKE) in daily clinics might reduce social and economic repercussion of this devastating disease.

On this basis, FIPSE program is a good opportunity to create and implement a specific valorization and commercialization plan to ultimately these treatments to the market, since the economical revenues of this strategy, if useful, would be massive.

A researcher from Biovendor at our lab

Tereza Mráčková, is a junior researcher who works at BioVendor – Laboratorní Medicína a.s. BioVendor LM is an internationally active biotechnology company with its own research, development and manufacturing and international sales and marketing network. It has specialized in the development of original immunoassay kits for the detection of novel hormone-like proteins and protein biomarkers as well as related antibodies and recombinant proteins. Recently they are also focusing on novel topics known to be of great interest among the scientific and diagnostic community – microRNA biomarkers, liquid biopsy, exosome isolation, and immunodiagnostic multiplexing and automation.

Tereza is also a PhD student in  the Stroke Program at the International Clinical Research Center (St. Anne’s University Hospital BRNO).

She is spending some days at our laboratory to test some miRNAs that could be connected to stroke diagnosis and prognosis.

 

 

 

Paper published at STEM CELLS

The Neurovascular Research Laboratory has published a new article  in collaboration with researchers of the Neuroprotection Research laboratory at Massachusetts General Hospital showing how Endothelial progenitor cells might participate in rescue from oxygen‐glucose deprivation by transferring mitochondria particles to damaged brain endothelial cells.

The investigation has been published at Stem Cells and one of the paper figures has illustrated the cover of the September’s issue.

These findings suggest that EPCs may support brain endothelial energetics, barrier integrity and angiogenic function partly through extracellular mitochondrial transfer, and support their potential use in stroke repair.

 

Hayakawa K, Chan SJ, Mandeville ET, Park JH, Bruzzese M, Montaner J, Arai K, Rosell A, Lo EH. Protective Effects of Endothelial Progenitor Cell-Derived Extracellular Mitochondria in Brain Endothelium. Stem Cells. 2018 Sep;36(9):1404-1410. doi: 10.1002/stem.2856.

 

First LIN retreat

 

 

On January 22nd, the neurovascular research laboratory held its first Retreat.

It has been an opportunity, especially for people who have recently joined the group, to learn a little about our history and the main lines of research.

We have had the collaboration of a gamification expert who has organised  games and quizzes focused on knowing each other. We have also put in common the objectives to achieve in 2018 and what we believe we can improve.

 

 

 

Dr. Anna Rosell will be the coordinator of a new H2020 project (EURONANOMED call)

Dr. Anna Rosell will be the coordinator of a new H2020 project (EURONANOMED call). 

Title: New MAGnetic Biomaterials for Brain Repair and Imaging after Stroke (MAGBBRIS)

According to the World Health Organization, 15 million persons suffer a stroke worldwide each year, and neuro-repair treatments could offer the opportunity to treat stroke patients by extending the therapeutic time window.

By engineering novel magnetic nano-biomaterials we will achieve tissue repair in the context of an ischemic event. We will take advantage of nanotechnology to deliver therapeutic growth factors, secreted by progenitor cells, into the injured brain. MAGBBRIS will demonstrate that growth factors, secreted by endothelial progenitor cells, with proved potential to induce tissue repair, can be encapsulated in magnetic biomaterials and be successfully and safely transplanted into mouse brains with the guidance of magnetic fields, to induce tissue repair.

MAGBBRIS consortium is made up by highly multidisciplinary materials-science, biomedical and clinical research with industrial partnership. The project will provide a new medicinal product ready to be tested in a preclinical multicentric study.

 

MAGBBRIS Partners

 

Dr. Anna Rosell, Vall d’Hebron Research Institute. Barcelona, Spain.

 

Dr. Anna Roig, Agencia Estatal Consejo Superior de Investigaciones Científicas (CSIC). Institut de Ciència de Materials de Barcelona (ICMAB). Bellaterra, Spain.

 

Dr. Fabien Gosselet, University of Artois, Faculty Jean Perrin. Lens, France.

 

Dr. Maria Picchio, Ospedale San Raffaele IRCCS. Milano, Italy.

 

Dr. Filip Jelen, Pure Biologics Ltd. Wrocław, Poland.

 

Dr. Peter Kopcansky, Institute of experimental physics, Slovak Academy of Sciences, SAS. Kosice, Slovakia.

 

New H2020 project: PRESTIGE AF

New H2020 project : PRESTIGE AF

PREvention of STroke in Intracerebral hemorrhaGE survivors with Atrial Fibrillation

Intracerebral hemorrhage (ICH) is a severe stroke subtype causing higher mortality and more disability than other strokes. 20% of ICH survivors have atrial fibrillation (AF), a major cause of ischemic stroke (IS). While IS in AF patients is generally prevented by oral anticoagulants (OAC), their use in ICH survivors is uncertain due to increased bleeding risk. No evidence from randomized controlled trials (RCT) is available addressing this dilemma. Personalized risk prediction is desirable to balance benefits of OAC against bleeding risk for individualized prevention.
Objectives: (1) To perform the first sufficiently powered RCT in ICH survivors with AF testing if direct OAC are superior for IS prevention and non-inferior regarding ICH recurrence versus antiplatelet or no antithrombotic therapy (2) To personalize antithrombotic prevention by multidimensional risk modeling (3) To estimate population impact of trial outputs on health economic consequences and generalizability to European population (4) To explore patient-centered aspects including
adherence, attitudes towards antithrombotic therapy and gender imbalances in trial enrollment.

PRESTIGE-AF addresses the unmet need of best antithrombotic stroke prevention in ICH patients with AF. Recurrent stroke reduces individual life expectancy, quality of life and has high public health impact. Work packages integrating biological data will generate new tools to tailor prevention. Modeling of economic and societal consequences and replication in real-life settings will estimate population impact.

 

Three LIN members have defended their doctoral thesis

In april and may three LIN members have defended their doctoral thesis.

Victor Llombart:  “Aplicaciones proteómicas para el descubrimiento de biomarcadores diagnósticos en ictus”

Alejandro Bustamante: “Condicionantes pronósticos del ictus isquémico: utilidad de los biomarcadores sanguíneos en su predicción”

Cristina Merino: “Identificación de biomarcadores en el ictus hemorrágico y su estudio funcional en modelos experimentales”

Congratulations to all of them!